TOWARD A REALISTIC MODEL OF MUTATIONS AFFECTING FITNESS

Peter D. Keightley; Michael Lynch

doi:10.1554/0014-3820(2003)057[0683:TARMOM]2.0.CO;2

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Peter D. Keightley,¹ Michael Lynch²

¹University of Edinburgh, Institute of Cell, Animal and Population Biology, West Mains Road, Edinburgh EH9 3JT, United Kingdom p.keightley@ed.ac.uk
²Indiana University, Department of Biology, Bloomington, Indiana 47405 mlynch@bio.indiana.edu

Abstract

Analysis of a recent mutation accumulation (MA) experiment has led to the suggestion that as many as one-half of spontaneous mutations in Arabidopsis are advantageous for fitness. We evaluate this in the light of data from other MA experiments, along with molecular evidence, that suggest the vast majority of new mutations are deleterious.

Citation Download Citation

Peter D. Keightley and Michael Lynch "TOWARD A REALISTIC MODEL OF MUTATIONS AFFECTING FITNESS," Evolution 57(3), 683-685, (1 March 2003). https://doi.org/10.1554/0014-3820(2003)057[0683:TARMOM]2.0.CO;2

Received: 16 July 2002; Accepted: 3 October 2002; Published: 1 March 2003